Immune-inflammatory responses and pulmonary embolism in Catatonia: A report of two cases

Jin-Jie Xu; Yanli Pan; Congcong Sun; Mingwan Wang; Yi-Lang Tang; Yanping Ren; Wei Wang; Gang Wang

doi:10.1016/j.ajp.2023.103693

Immune-inflammatory responses and pulmonary embolism in Catatonia: A report of two cases

Asian J Psychiatr. 2023 Sep:87:103693. doi: 10.1016/j.ajp.2023.103693. Epub 2023 Jul 8.

Authors

Jin-Jie Xu¹, Yanli Pan², Congcong Sun², Mingwan Wang², Yi-Lang Tang³, Yanping Ren⁴, Wei Wang⁵, Gang Wang⁶

Affiliations

¹ Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. Electronic address: sjmedical_xjj@mail.ccmu.edu.cn.
² Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
³ Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30329, USA; Mental Health Service Line, Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur, GA 30033, USA.
⁴ Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. Electronic address: renyanping@ccmu.edu.cn.
⁵ Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. Electronic address: seeyou2008@mail.ccmu.edu.cn.
⁶ Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China. Electronic address: gangwangdoc@ccmu.edu.cn.

PMID: 37437347
DOI: 10.1016/j.ajp.2023.103693

Abstract

Venous thromboembolism (VTE) comprises pulmonary embolism (PE) and deep vein thrombosis (DVT). PE, as the most severe manifestation of VTE, can cause increased mortality in patients with mental disorders. Here we describe two cases of young male patients with catatonia who developed PE and DVT during their hospital stay. We also discuss the possible pathogenesis, with a focus on immune and inflammatory mechanisms.

Keywords: Catatonia; Deep vein thrombosis; Immune-Inflammatory Mechanisms; Pulmonary embolism; Venous thromboembolism.

Publication types

Case Reports
Letter

MeSH terms

Catatonia* / etiology
Humans
Male
Pulmonary Embolism* / complications
Risk Factors
Venous Thromboembolism*
Venous Thrombosis* / complications