Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMI

Patrick J Beck; John Benfield; Joshua Morales

doi:10.1155/2023/5926340

Friend or Foe: Factor XII Deficiency Discovered Incidentally during Management of NSTEMI

Case Rep Hematol. 2023 Jun 29:2023:5926340. doi: 10.1155/2023/5926340. eCollection 2023.

Authors

Patrick J Beck¹, John Benfield^{1

2}, Joshua Morales^{1

2

3}

Affiliations

¹ Virginia Tech Carilion School of Medicine, 2 Riverside Circle, Roanoke, VA 24016, USA.
² Department of Internal Medicine, Carilion Roanoke Memorial Hospital, 1906 Belleview Ave SE, Roanoke, VA 24014, USA.
³ Blue Ridge Cancer Care, 2013 S Jefferson St, Roanoke, VA 24014, USA.

Abstract

Factor XII (FXII) deficiency is a rare coagulopathy that typically goes undiagnosed due to the lack of abnormal bleeding or thrombosis. However, the accompanying prolonged activated partial thromboplastin time (aPTT) can create difficulties with maintaining therapeutic anticoagulation in the setting of acute coronary syndrome (ACS). Here, we present the case of a 52-year-old man presenting with chest pain and diagnosed with an NSTEMI but also found with a prolonged baseline aPTT ultimately secondary to FXII deficiency. Here, we discuss the diagnostic work-up of an isolated prolonged aPTT to identify possible etiologies, such as FXII deficiency, and ultimately inform ACS management.

Publication types

Case Reports