Generation of a human Tropomyosin 1 knockout iPSC line

Madison B Wilken; Jean Ann Maguire; Lea V Dungan; Alyssa Gagne; Catherine Osorio-Quintero; Elisa A Waxman; Stella T Chou; Paul Gadue; Deborah L French; Christopher S Thom

doi:10.1016/j.scr.2023.103161

Generation of a human Tropomyosin 1 knockout iPSC line

Stem Cell Res. 2023 Sep:71:103161. doi: 10.1016/j.scr.2023.103161. Epub 2023 Jun 28.

Affiliations

¹ Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
² Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
³ Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁴ Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁵ Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: thomc@chop.edu.

Abstract

The CHOPWT17_TPM1KOc28 iPSC line was generated to interrogate the functions of Tropomyosin 1 (TPM1) in primary human cell development. This line was reprogrammed from a previously published wild type control iPSC line.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Cell Line, Tumor
Humans
Induced Pluripotent Stem Cells* / metabolism
Tropomyosin* / genetics
Tropomyosin* / metabolism

Substances

Tropomyosin

Generation of a human Tropomyosin 1 knockout iPSC line

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

Grants and funding