Postacute Sequelae of SARS-CoV-2: Musculoskeletal Conditions and Pain

Michelle Copley; Barbara Kozminski; Nicole Gentile; Rachel Geyer; Janna Friedly

doi:10.1016/j.pmr.2023.04.008

Postacute Sequelae of SARS-CoV-2: Musculoskeletal Conditions and Pain

Phys Med Rehabil Clin N Am. 2023 Aug;34(3):585-605. doi: 10.1016/j.pmr.2023.04.008. Epub 2023 Apr 14.

Authors

Michelle Copley¹, Barbara Kozminski¹, Nicole Gentile², Rachel Geyer³, Janna Friedly⁴

Affiliations

¹ Department of Rehabilitation Medicine, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA.
² Department of Family Medicine, University of Washington, 1959 Northeast Pacific Street, Box 356390, Seattle, WA 98195-6390, USA; Department of Laboratory Medicine and Pathology, University of Washington, 1959 Northeast Pacific Street Seattle, WA 98195-6390, USA.
³ Department of Family Medicine, University of Washington, 1959 Northeast Pacific Street, Box 356390, Seattle, WA 98195-6390, USA.
⁴ Department of Rehabilitation Medicine, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA. Electronic address: Friedlyj@uw.edu.

Abstract

Musculoskeletal and pain sequelae of COVID-19 are common in both the acute infection and patients experiencing longer term symptoms associated with recovery, known as postacute sequelae of COVID-19 (PASC). Patients with PASC may experience multiple manifestations of pain and other concurrent symptoms that complicate their experience of pain. In this review, the authors explore what is currently known about PASC-related pain and its pathophysiology as well as strategies for diagnosis and management.

Keywords: COVID-related pain; Long COVID; Musculoskeletal conditions; PASC; Pain.

Publication types

Review

MeSH terms

COVID-19* / complications
Humans
Musculoskeletal Diseases* / diagnosis
Musculoskeletal Diseases* / etiology
Pain
Post-Acute COVID-19 Syndrome
SARS-CoV-2