Endoplasmic reticulum homeostasis: a potential target for diabetic nephropathy

Ming Yang; Chongbin Liu; Na Jiang; Yan Liu; Shilu Luo; Chenrui Li; Hao Zhao; Yachun Han; Wei Chen; Li Li; Li Xiao; Lin Sun

doi:10.3389/fendo.2023.1182848

Endoplasmic reticulum homeostasis: a potential target for diabetic nephropathy

Front Endocrinol (Lausanne). 2023 Jun 13:14:1182848. doi: 10.3389/fendo.2023.1182848. eCollection 2023.

Authors

Ming Yang^{1

2}, Chongbin Liu^{1

2}, Na Jiang^{1

2}, Yan Liu^{1

2}, Shilu Luo^{1

2}, Chenrui Li^{1

2}, Hao Zhao^{1

2}, Yachun Han^{1

2}, Wei Chen^{1

2}, Li Li^{1

2}, Li Xiao^{1

2}, Lin Sun^{1

2}

Affiliations

¹ Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China.

Abstract

The endoplasmic reticulum (ER) is the most vigorous organelle in intracellular metabolism and is involved in physiological processes such as protein and lipid synthesis and calcium ion transport. Recently, the abnormal function of the ER has also been reported to be involved in the progression of kidney disease, especially in diabetic nephropathy (DN). Here, we reviewed the function of the ER and summarized the regulation of homeostasis through the UPR and ER-phagy. Then, we also reviewed the role of abnormal ER homeostasis in residential renal cells in DN. Finally, some ER stress activators and inhibitors were also summarized, and the possibility of maintaining ER homeostasis as a potential therapeutic target for DN was discussed.

Keywords: ER stress; ER-phagy; UPR; diabetic nephropathy; endoplasmic reticulum (ER).

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Diabetes Mellitus*
Diabetic Nephropathies* / drug therapy
Endoplasmic Reticulum
Endoplasmic Reticulum Stress
Epithelial Cells
Homeostasis
Humans

Grants and funding

This work was supported by the Natural Science Foundation of Hunan Province (2021JC0003).