Decoding a ribosome uncertainty

Olivier Duss; Rainer Nikolay; Matthew L Kraushar

doi:10.1016/j.tig.2023.06.001

Decoding a ribosome uncertainty

Trends Genet. 2023 Sep;39(9):639-641. doi: 10.1016/j.tig.2023.06.001. Epub 2023 Jun 26.

Authors

Olivier Duss¹, Rainer Nikolay², Matthew L Kraushar³

Affiliations

¹ European Molecular Biology Laboratory, Heidelberg, Germany. Electronic address: olivier.duss@embl.de.
² Max Planck Institute for Molecular Genetics, Berlin, Germany. Electronic address: nikolay@molgen.mpg.de.
³ Max Planck Institute for Molecular Genetics, Berlin, Germany. Electronic address: matthew.kraushar@molgen.mpg.de.

PMID: 37380507
DOI: 10.1016/j.tig.2023.06.001

Abstract

The ribosome is among the most ancient macromolecular complexes. Throughout evolution, the function of the ribosome has remained essential and conserved: the decoding of an mRNA template with tRNA-linked amino acids, to synthesize a protein. In a recent study, Holm et al. capture evolutionary distinctions in the structure and kinetics of 'mRNA decoding' by the human ribosome.

Publication types

Comment

MeSH terms

Humans
Protein Biosynthesis* / genetics
RNA, Messenger / metabolism
RNA, Transfer / genetics
Ribosomes* / genetics
Ribosomes* / metabolism
Uncertainty

Substances

RNA, Messenger
RNA, Transfer