Future Approaches and Therapeutic Modalities for Acute-on-Chronic Liver Failure

Ali Wakil; Mumtaz Niazi; Keri E Lunsford; Nikolaos Pyrsopoulos

doi:10.1016/j.cld.2023.03.017

Future Approaches and Therapeutic Modalities for Acute-on-Chronic Liver Failure

Clin Liver Dis. 2023 Aug;27(3):777-790. doi: 10.1016/j.cld.2023.03.017. Epub 2023 Apr 27.

Authors

Ali Wakil¹, Mumtaz Niazi¹, Keri E Lunsford², Nikolaos Pyrsopoulos³

Affiliations

¹ Division of Gastroenterology and Hepatology, Department of Medicine, Rutgers New Jersey Medical School, 185 South Orange Avenue, MSB H536, Newark, NJ 07103, USA.
² Department of Surgery, Division of Liver Transplant and HPB Surgery, Rutgers New Jersey Medical School, 185 South Orange Avenue, MSB H536, Newark, NJ 07103, USA.
³ Division of Gastroenterology and Hepatology, Department of Medicine, Rutgers New Jersey Medical School, 185 South Orange Avenue, MSB H536, Newark, NJ 07103, USA. Electronic address: pyrsopni@njms.rutgers.edu.

PMID: 37380297
DOI: 10.1016/j.cld.2023.03.017

Abstract

Acute-on-chronic liver failure (ACLF) results from an acute decompensation of cirrhosis due to exogenous insult. The condition is characterized by a severe systemic inflammatory response, inappropriate compensatory anti-inflammatory response, multisystem extrahepatic organ failure, and high short-term mortality. Here, the authors evaluate the current status of potential treatments for ACLF and assess their efficacy and therapeutic potential.

Keywords: ACLF emerging therapies; Liver stem cell transplant; Liver support devices.

Publication types

Review

MeSH terms

Acute-On-Chronic Liver Failure* / etiology
Acute-On-Chronic Liver Failure* / therapy
Humans
Liver Cirrhosis / complications
Liver Cirrhosis / therapy