Eradication of Burkholderia cepacia complex in cystic fibrosis patients with inhalation of amiloride and tobramycin combined with oral cotrimoxazole

Anne M Akkerman-Nijland; Bart L Rottier; Joanne Holstein; Rik L J Winter; Daniel J Touw; Onno W Akkerman; Gerard H Koppelman

doi:10.1183/23120541.00055-2023

Eradication of Burkholderia cepacia complex in cystic fibrosis patients with inhalation of amiloride and tobramycin combined with oral cotrimoxazole

ERJ Open Res. 2023 Jun 26;9(3):00055-2023. doi: 10.1183/23120541.00055-2023. eCollection 2023 May.

Authors

Anne M Akkerman-Nijland^{1

2}, Bart L Rottier^{1

2}, Joanne Holstein³, Rik L J Winter⁴, Daniel J Touw^{2

5}, Onno W Akkerman³, Gerard H Koppelman^{1

2}

Affiliations

¹ University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, Groningen, the Netherlands.
² University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands.
³ University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases and Tuberculosis, University of Groningen, Groningen, the Netherlands.
⁴ University of Groningen, University Medical Center Groningen, Department of Microbiology, Groningen, The Netherlands.
⁵ University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy & Pharmacology, University of Groningen, Groningen, The Netherlands.

Abstract

This case series suggests that successful eradication therapy of BCC in cystic fibrosis can be done with a combination of inhaled and oral medication, which in many cases may eliminate the need for intensive treatment with intravenous antibiotics https://bit.ly/40oOMIn.