Diagnostic Accuracy of Group A Streptococcus Rapid Antigen Detection Test on Middle Ear Fluid in Children With Acute Otitis Media With Spontaneous Perforation: A Prospective Multicenter Evaluation

Robert Cohen; Emmanuelle Varon; Philippe Bidet; Jérémie F Cohen; Stéphane Béchet; Vincent Couloigner; Anne Sylvestre Michot; Cécile Guiheneuf; Stéphane Bonacorsi; Corinne Levy

doi:10.1097/INF.0000000000004009

Diagnostic Accuracy of Group A Streptococcus Rapid Antigen Detection Test on Middle Ear Fluid in Children With Acute Otitis Media With Spontaneous Perforation: A Prospective Multicenter Evaluation

Pediatr Infect Dis J. 2023 Sep 1;42(9):816-818. doi: 10.1097/INF.0000000000004009. Epub 2023 Jun 22.

Authors

Robert Cohen^{1

2

3

4}, Emmanuelle Varon⁵, Philippe Bidet^{6

7}, Jérémie F Cohen^{8

9}, Stéphane Béchet^{1

4}, Vincent Couloigner¹⁰, Anne Sylvestre Michot^{1

4}, Cécile Guiheneuf⁴, Stéphane Bonacorsi^{6

7}, Corinne Levy^{1

2

3

4}

Affiliations

¹ From the ACTIV, Association Clinique et Thérapeutique Infantile du Val-de-Marne, Créteil, France.
² Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Créteil, Créteil, France.
³ Université Paris Est, IMRB-GRC GEMINI, Créteil, France.
⁴ AFPA, Association Française de Pédiatrie Ambulatoire, Orléans, France.
⁵ Service de microbiologie, Hôpital Intercommunal de Créteil, Créteil, France.
⁶ Université Paris Cité, IAME, INSERM, Paris, France.
⁷ Service de microbiologie, Hôpital Robert-Debré, AP-HP, Paris, France.
⁸ Department of General Pediatrics and Pediatric Infectious Diseases, Hôpital Necker-Enfants malades, AP-HP, Université Paris Cité, Paris, France.
⁹ Centre of Research in Epidemiology and Statistics (Inserm UMR 1153), Université Paris Cité, Paris, France.
¹⁰ Department of ENT, Hôpital Necker-Enfants malades, AP-HP, Université Paris Cité, Paris, France.

Abstract

Group A Streptococcus is one of the leading causes of otorrhea. The performance of rapid antigen tests in 256 children with otorrhea showed excellent sensitivity, 97.3% (95% confidence interval: 90.7%-99.7%), and specificity, 100% (95% confidence interval: 98.0%-100%). In a period of increasing invasive and noninvasive group A Streptococcus infections, an early diagnosis could be useful.

Trial registration: ClinicalTrials.gov NCT04807660.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Child
Ear, Middle
Humans
Infant
Otitis Media with Effusion* / etiology
Otitis Media* / complications
Pneumococcal Infections* / complications
Prospective Studies
Spontaneous Perforation / complications
Streptococcus pneumoniae
Streptococcus pyogenes

Associated data

ClinicalTrials.gov/NCT04807660