Caffeine Limits Expansion of Apc-Deficient Clones in the Intestine by NOTUM Inhibition

Milou S van Driel; Jasmijn D G Linssen; Dustin J Flanagan; Nikola Vlahov; Lisanne E Nijman; Nina E de Groot; Clara C Elbers; Jan Koster; Owen J Sansom; Louis Vermeulen; Sanne M van Neerven

doi:10.1016/j.jcmgh.2023.06.008

Caffeine Limits Expansion of Apc-Deficient Clones in the Intestine by NOTUM Inhibition

Cell Mol Gastroenterol Hepatol. 2023;16(4):652-655. doi: 10.1016/j.jcmgh.2023.06.008. Epub 2023 Jun 24.

Authors

Affiliations

¹ Amsterdam UMC, Location University of Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands; Oncode Institute, Amsterdam, The Netherlands.
² Amsterdam UMC, Location University of Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands; Oncode Institute, Amsterdam, The Netherlands; Amsterdam UMC, Location University of Amsterdam, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands.
³ Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia; Cancer Program, Biomedicine Discovery Institute, Monash University, Melbourne, Australia; Cancer Research UK Beatson Institute, Glasgow, United Kingdom.
⁴ Cancer Research UK Beatson Institute, Glasgow, United Kingdom.
⁵ Amsterdam UMC, Location University of Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands.
⁶ Cancer Research UK Beatson Institute, Glasgow, United Kingdom; Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.
⁷ Amsterdam UMC, Location University of Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands; Oncode Institute, Amsterdam, The Netherlands. Electronic address: l.vermeulen@amsterdamumc.nl.
⁸ Amsterdam UMC, Location University of Amsterdam, Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands; Oncode Institute, Amsterdam, The Netherlands; Wellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom. Electronic address: s.m.vanneerven@amsterdamumc.nl.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Caffeine* / pharmacology
Clone Cells
Intestines*

Substances

Caffeine