Multicenter study of some liver and heart function tests in SARS-Cov-2 patients from three ethnic groups in Iran

Seyed Majid Fatahi; Hadi Razavi Nikoo; Ali Safarzadeh; Gholam Reza Talei; Sayyad Khanizadeh; Ashkan Alamdary; Rasool Mohammadi; Mehdi Ajorloo

doi:10.1007/s13337-023-00818-x

Multicenter study of some liver and heart function tests in SARS-Cov-2 patients from three ethnic groups in Iran

Virusdisease. 2023 May 3;34(2):1-7. doi: 10.1007/s13337-023-00818-x. Online ahead of print.

Authors

Seyed Majid Fatahi^#¹, Hadi Razavi Nikoo^#^{2

3}, Ali Safarzadeh⁴, Gholam Reza Talei⁵, Sayyad Khanizadeh⁵, Ashkan Alamdary⁶, Rasool Mohammadi⁷, Mehdi Ajorloo^{5

8}

Affiliations

¹ Khorramabad, Iran Student Research Committee, Lorestan University of Medical Sciences.
² Gorgan, Iran Infectious Disease Research Center, Golestan University of Medical Sciences.
³ Gorgan, Iran Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences.
⁴ Padova, Italy Department of Biology, University of Padova.
⁵ Khorramabad, Iran Hepatitis Research Center, Department of Virology, Faculty of Medicine, Lorestan University of Medical Sciences.
⁶ Tehran, Iran Department of Biology, Science and Research Branch, Islamic Azad University.
⁷ Khorramabad, Iran Nutritional Health Research Center, Health and Nutritional Department, Lorestan University of Medical Sciences.
⁸ Tehran, Iran Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.

^# Contributed equally.

Abstract

The liver and cardiovascular system disorders are not common in COVID-19 patients, but the patients suffering from these complications are exposed to a higher rate of mortality and disease progression. Hepatic injuries can drive to increased levels of liver enzymes, including ALT, AST, and LDH. Abundant levels of AST, LDH, and CPK can be indicators of cardiac injuries. The current study comparise 366 individuals who are divided into COVID-19 patients and healthy individuals groups, in which we have examined hepatic and cardiac function parameters. Moreover, the clinical characteristics of the participants, ethnicities, and their difference with studied parameters were assessed. The results showed Fars individuals are more susceptible to the disease progression, including liver and heart damage. COVID-19 infection is associated with aging, which indicates that the mean age of the case group is ten years older than the control group (P < 0.001). The blood sugar in the case group (140.50) was higher than in the control group (131.66), although there was no difference between the infection and BS (P = 0.505). Similarly, the increased- mean of the ALT level in the case group (102.369) compared with the control group (68.324) resulted in no significant difference (P = 0.318). Other parameters, including CPK, LDH, and AST showed an increase in the control group values compared to the case group; however, the differences were not significant (P = 0.264, P = 0.795, P = 0.417). Considering the involvement of cardiac and hepatic organs by SARS-CoV-2, paying particular attention to the disorders of these organs through assessing the hepatic and cardiac function parameters can enhance the patient's recovery and survival. However, in this study, we not observed significant differences, except for the Fars people. There is need for further assessment of this issue.

Keywords: COVID-19; Heart function test; Liver function test; SARS-CoV-2.

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