Clinical associations of BRAF and MAP2K1 mutations in pediatric Langerhans cell histiocytosis: When 1 + 1 = 3

Am J Hematol. 2023 Sep;98(9):E244-E246. doi: 10.1002/ajh.27008. Epub 2023 Jun 26.

Authors

Paul G Kemps^{1

2}, Cor van den Bos^{2

3}, Astrid G S van Halteren^{1

2

4}; International Study Group

Affiliations

¹ Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
² Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
³ Department of Pediatric Oncology, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
⁴ Department of Internal Medicine, Section Clinical Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

PMID: 37357851
DOI: 10.1002/ajh.27008

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Child
Genetic Predisposition to Disease
Histiocytosis, Langerhans-Cell* / genetics
Humans
MAP Kinase Kinase 1 / genetics
Mutation
Proto-Oncogene Proteins B-raf* / genetics

Substances

Proto-Oncogene Proteins B-raf
BRAF protein, human
MAP2K1 protein, human
MAP Kinase Kinase 1