The role of IL-17 in lung cancer growth

Liping Liu; Renli Liu; Chaojie Wei; Dong Li; Xiuzhu Gao

doi:10.1016/j.cyto.2023.156265

The role of IL-17 in lung cancer growth

Cytokine. 2023 Sep:169:156265. doi: 10.1016/j.cyto.2023.156265. Epub 2023 Jun 20.

Authors

Liping Liu¹, Renli Liu¹, Chaojie Wei¹, Dong Li², Xiuzhu Gao³

Affiliations

¹ Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China.
² Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, China. Electronic address: lidong1@jlu.edu.cn.
³ Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun, China. Electronic address: xiuzhugao@jlu.edu.cn.

PMID: 37348188
DOI: 10.1016/j.cyto.2023.156265

Abstract

Interleukin 17 (IL-17) is an inflammatory cytokine with multiple roles in immune protection, immunopathology, and inflammation-related tumors. Lung cancer is inflammation-related cancer, and a large number of studies have shown that IL-17 contributes to the metastasis and progression of lung cancer. However, some studies have shown that IL17 inhibits the occurrence of lung cancer. At present, there is still some controversy about the role of IL17 in the occurrence and development of lung cancer. This review introduces the basic characteristics of IL-17 and focuses on its role in lung cancer, in order to provide a certain theoretical basis for the prevention, diagnosis, and treatment of lung cancer.

Keywords: IL17; Inflammation; Lung cancer.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cytokines
Humans
Inflammation
Interleukin-17*
Lung Neoplasms* / pathology

Substances

Interleukin-17
Cytokines