DC-86-M, a novel antitumor antibiotic. II. Structure determination and biological activities

J Antibiot (Tokyo). 1986 May;39(5):624-8. doi: 10.7164/antibiotics.39.624.

Abstract

A novel antibiotic, DC-86-M was isolated from the culture broth of Streptomyces luteogriseus DO-86. The antibiotic has the molecular formula of C17H14N2O5 and belongs to the phenazine antibiotics. Its structure has been elucidated by mass and NMR spectra. It is active against Gram-positive and Gram-negative bacteria and experimental murine sarcoma 180.

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic* / isolation & purification
  • Antibiotics, Antineoplastic* / therapeutic use
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Magnetic Resonance Spectroscopy
  • Mice
  • Phenazines / isolation & purification
  • Phenazines / pharmacology
  • Phenazines / therapeutic use
  • Sarcoma 180 / drug therapy
  • Spectrophotometry, Ultraviolet
  • Streptomyces

Substances

  • Antibiotics, Antineoplastic
  • Phenazines
  • DC 86M