CIP2A and TOPBP1: Molecular lassos that herd pulverized micronuclear chromosomes

Chaithanya P Vedula; Neil J Ganem

doi:10.1016/j.molcel.2023.05.032

CIP2A and TOPBP1: Molecular lassos that herd pulverized micronuclear chromosomes

Mol Cell. 2023 Jun 15;83(12):1964-1966. doi: 10.1016/j.molcel.2023.05.032.

Authors

Chaithanya P Vedula¹, Neil J Ganem²

Affiliations

¹ Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
² Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. Electronic address: nganem@bu.edu.

PMID: 37327773
DOI: 10.1016/j.molcel.2023.05.032

Abstract

Lin et al.¹ demonstrate that acentric chromosome fragments generated within micronuclei are tethered by the CIP2A-TOPBP1 complex during mitosis, thus promoting clustered segregation of the fragments to a single daughter cell nucleus and facilitating re-ligation with limited chromosomal scattering and loss.

MeSH terms

Cell Nucleus*
Chromosome Segregation
Chromosomes*
Mitosis