Gas-free alkoxycarbonylation of aryl iodides in a phosphonium-based deep eutectic solvent with Mo(CO)6 as a solid CO source

Org Biomol Chem. 2023 Jun 28;21(25):5164-5170. doi: 10.1039/d3ob00596h.

Abstract

Pd-catalyzed alkoxycarbonylation of aryl iodides has been explored, for the first time, in phosphonium-based deep eutectic solvents under gas-free conditions, by using Mo(CO)6 as the CO source. The method allows the preparation of ethylene glycol and glycerol esters in high yields (up to 99%), short reaction times and under mild reaction conditions with a very low catalyst loading (0.5 mol%).