Soaping up transcriptional condensates

Min Kyung Shinn; Rohit V Pappu

doi:10.1016/j.devcel.2023.05.002

Soaping up transcriptional condensates

Dev Cell. 2023 Jun 5;58(11):915-916. doi: 10.1016/j.devcel.2023.05.002.

Authors

Min Kyung Shinn¹, Rohit V Pappu²

Affiliations

¹ Department of Biomedical Engineering and Center for Biomolecular Condensates, James F. McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
² Department of Biomedical Engineering and Center for Biomolecular Condensates, James F. McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA. Electronic address: pappu@wustl.edu.

PMID: 37279696
DOI: 10.1016/j.devcel.2023.05.002

Abstract

The condensate-forming ability of transcription factors (TFs) has received considerable attention, although how condensates function in transcription remains unclear. In this issue of Developmental Cell, Wang et al. show that target DNA and transcriptional regulators work as soap-like surfactants to adsorb on condensates, affecting the activities of transcriptional condensates.

Publication types

Comment

MeSH terms

DNA / genetics
Nuclear Bodies
Soaps*
Transcription Factors* / genetics

Substances

Soaps
Transcription Factors
DNA