A genome-wide association study of antidepressant-induced mania

Clement C Zai; Alessio Squassina; Arun K Tiwari; Claudia Pisanu; Marco Pinna; Federica Pinna; Anna Meloni; Pasquale Paribello; Bernardo Carpiniello; Leonardo Tondo; Mark A Frye; Joanna M Biernacka; Brandon J Coombes; James L Kennedy; Mirko Manchia

doi:10.1016/j.pnpbp.2023.110800

A genome-wide association study of antidepressant-induced mania

Prog Neuropsychopharmacol Biol Psychiatry. 2023 Dec 20:127:110800. doi: 10.1016/j.pnpbp.2023.110800. Epub 2023 May 24.

Authors

Affiliations

¹ Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Department of Psychiatry, University of Toronto, Canada; Institute of Medical Science, University of Toronto, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Canada; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, United States of America. Electronic address: clement.zai@camh.ca.
² Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Cagliari, Italy.
³ Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Department of Psychiatry, University of Toronto, Canada.
⁴ Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, Italy; Lucio Bini Mood Disorders Center, Cagliari, Italy.
⁵ Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, Italy; Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09124 Cagliari, Italy.
⁶ Lucio Bini Mood Disorders Center, Cagliari, Italy; McLean Hospital-Harvard Medical School, Boston, USA.
⁷ Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
⁸ Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
⁹ Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
¹⁰ Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Department of Psychiatry, University of Toronto, Canada; Institute of Medical Science, University of Toronto, Canada.
¹¹ Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, Italy; Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09124 Cagliari, Italy; Department of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada; McLean Hospital-Harvard Medical School, Boston, USA.

PMID: 37236419
DOI: 10.1016/j.pnpbp.2023.110800

Abstract

Antidepressant-induced mania (AIM) is a side effect of antidepressant treatment that is characterized by mania or hypomania after the start of medication. It is likely polygenic, but its genetic component remains largely unexplored. We aim to conduct the first genome-wide association study of AIM in 814 bipolar disorder patients of European ancestry. We report no significant findings from our single-marker or gene-based analyses. Our polygenic risk score analyses also did not yield significant results with bipolar disorder, antidepressant response, or lithium response. Our suggestive findings on the hypothalamic-pituitary-adrenal axis and the opioid system in AIM require independent replications.

Keywords: Antidepressant-induced mania; Bipolar disorder; Depression; Genome-wide association study; Pharmacogenetics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antidepressive Agents / therapeutic use
Genome-Wide Association Study*
Humans
Hypothalamo-Hypophyseal System
Mania* / drug therapy
Pituitary-Adrenal System

Substances

Antidepressive Agents