Significant Association of Cutavirus With Parapsoriasis en Plaques: High Prevalence Both in Skin Swab and Biopsy Samples

Ushanandini Mohanraj; Tuomas Konttinen; Alexander Salava; Liisa Väkevä; Annamari Ranki; Maria Söderlund-Venermo

doi:10.1093/cid/ciad320

Significant Association of Cutavirus With Parapsoriasis en Plaques: High Prevalence Both in Skin Swab and Biopsy Samples

Clin Infect Dis. 2023 Oct 5;77(7):987-990. doi: 10.1093/cid/ciad320.

Authors

Ushanandini Mohanraj¹, Tuomas Konttinen^{1

2

3}, Alexander Salava⁴, Liisa Väkevä⁴, Annamari Ranki⁴, Maria Söderlund-Venermo¹

Affiliations

¹ Department of Virology, University of Helsinki, Helsinki, Finland.
² Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
³ Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
⁴ Department of Dermatology, Allergology, and Venereology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

Abstract

Cutavirus (CuV) is associated with cutaneous T-cell lymphoma (CTCL), of which parapsoriasis is a precursor. Our study reveals a significantly higher CuV-DNA prevalence in skin swabs of parapsoriasis patients (6/13; 46.2%) versus those of healthy adults (1/51; 1.96%). Eight patients (8/12; 66.7%) had CuV DNA in biopsied skin, and 4 developed CTCL.

Keywords: cutaneous T-cell lymphoma; disease association; in situ hybridization; parapsoriasis; protoparvovirus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Biopsy
DNA
Humans
Lymphoma, T-Cell, Cutaneous*
Parapsoriasis* / genetics
Parapsoriasis* / pathology
Prevalence
Skin Neoplasms* / pathology

Substances

DNA