Today's Kaposi sarcoma is not the same as it was 40 years ago, or is it?

Blossom Damania; Dirk P Dittmer

doi:10.1002/jmv.28773

Today's Kaposi sarcoma is not the same as it was 40 years ago, or is it?

J Med Virol. 2023 May;95(5):e28773. doi: 10.1002/jmv.28773.

Authors

Blossom Damania¹, Dirk P Dittmer¹

Affiliation

¹ Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Abstract

This review will provide an overview of the notion that Kaposi sarcoma (KS) is a disease that manifests under diverse and divergent circumstances. We begin with a historical introduction of KS and KS-associated herpesvirus (KSHV), highlight the diversity of clinical presentations of KS, summarize what we know about the cell of origin for this tumor, explore KSHV viral load as a potential biomarker for acute KSHV infections and KS-associated complications, and discuss immune modulators that impact KSHV infection, KSHV persistence, and KS disease.

Keywords: KSHV; Kaposi sarcoma; herpesvirus.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Herpesvirus 8, Human*
Humans
Sarcoma, Kaposi*
Viral Load

Abstract

Publication types

MeSH terms

Grants and funding