Protocols for D-Dimer Measurements for Aid to Diagnosis or Exclusion of Venous Thromboembolism

Robert C Gosselin

doi:10.1007/978-1-0716-3175-1_8

Protocols for D-Dimer Measurements for Aid to Diagnosis or Exclusion of Venous Thromboembolism

Methods Mol Biol. 2023:2663:127-161. doi: 10.1007/978-1-0716-3175-1_8.

Author

Robert C Gosselin¹

Affiliation

¹ University of California, Davis Health System, Thrombosis & Hemostasis Center, Sacramento, CA, USA.

PMID: 37204708
DOI: 10.1007/978-1-0716-3175-1_8

Abstract

Measuring D-dimer is commonly used as a surrogate to indicate a clot-forming process, with subsequent lysis. This test has two primary intended uses: (1) as aid to diagnosis of various conditions and (2) venous thromboembolism (VTE) exclusion. If the manufacturer cites a VTE exclusion claim, the D-dimer test must only be used in evaluating patients with a non-high or unlikely pretest probability for pulmonary embolism and deep vein thrombosis. D-dimer kits with only aid to diagnosis claim should not be used for VTE exclusion. The intended use of the D-dimer may vary by region, and readership should consult manufacturer instructions for use to assure proper use of the assay. In this chapter, several methods for measuring D-dimer will be described.

Keywords: Aid to diagnosis; D-Dimer; Deep vein thrombosis; ELFA; ELISA; FRET; LIA; POC; Pulmonary embolism; Venous thromboembolism.

MeSH terms

Fibrin Fibrinogen Degradation Products
Humans
Pulmonary Embolism* / diagnosis
Venous Thromboembolism* / diagnosis
Venous Thrombosis* / diagnosis

Substances

fibrin fragment D
Fibrin Fibrinogen Degradation Products