Boosting NKCC1 in the choroid plexus: From CSF clearance to a potential therapy for posthemorrhagic hydrocephalus

Inyoung Jeong; Nathalie Jurisch-Yaksi

doi:10.1016/j.neuron.2023.04.014

Boosting NKCC1 in the choroid plexus: From CSF clearance to a potential therapy for posthemorrhagic hydrocephalus

Neuron. 2023 May 17;111(10):1521-1523. doi: 10.1016/j.neuron.2023.04.014.

Authors

Inyoung Jeong¹, Nathalie Jurisch-Yaksi²

Affiliations

¹ Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Erling Skjalgsons Gate 1, 7491 Trondheim, Norway.
² Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Erling Skjalgsons Gate 1, 7491 Trondheim, Norway. Electronic address: nathalie.jurisch-yaksi@ntnu.no.

PMID: 37201502
DOI: 10.1016/j.neuron.2023.04.014

Abstract

In this issue of Neuron, Sadegh et al.¹ identify a novel potential therapeutical target for posthemorrhagic hydrocephalus (PHH). The authors identified that overexpression of Na-K-2Cl cotransporter-1 (NKCC1) in the choroid plexus relieves ventriculomegaly and enhances cerebrospinal fluid (CSF) clearance in improved PHH mouse models.

Publication types

Comment

MeSH terms

Animals
Choroid Plexus
Disease Models, Animal
Hydrocephalus* / etiology
Mice
Symporters*

Substances

Symporters