Ultrasound-responsive matters for biomedical applications

Danqing Huang; Jinglin Wang; Chuanhui Song; Yuanjin Zhao

doi:10.1016/j.xinn.2023.100421

Ultrasound-responsive matters for biomedical applications

Innovation (Camb). 2023 Apr 6;4(3):100421. doi: 10.1016/j.xinn.2023.100421. eCollection 2023 May 15.

Authors

Danqing Huang¹, Jinglin Wang¹, Chuanhui Song¹, Yuanjin Zhao^{1

2

3}

Affiliations

¹ Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210002, China.
² State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
³ Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China.

Abstract

Ultrasound (US) is a biofavorable mechanical wave that has shown practical significance in biomedical fields. Due to the cavitation effect, sonoluminescence, sonoporation, pyrolysis, and other biophysical and chemical effects, a wide range of matters have been elucidated to be responsive to the stimulus of US. This review addresses and discusses current developments in US-responsive matters, including US-breakable intermolecular conjugations, US-catalytic sonosensitizers, fluorocarbon compounds, microbubbles, and US-propelled micro- and nanorobots. Meanwhile, the interactions between US and advanced matters create various biochemical products and enhanced mechanical effects, leading to the exploration of potential biomedical applications, from US-facilitated biosensing and diagnostic imaging to US-induced therapeutic applications and clinical translations. Finally, the current challenges are summarized and future perspectives on US-responsive matters in biomedical applications and clinical translations are proposed.

Publication types

Review