Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer

Javad Alizadeh; Mahboubeh Kavoosi; Navjit Singh; Shahrokh Lorzadeh; Amir Ravandi; Biniam Kidane; Naseer Ahmed; Fatima Mraiche; Michael R Mowat; Saeid Ghavami

doi:10.3390/cancers15082195

Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer

Cancers (Basel). 2023 Apr 7;15(8):2195. doi: 10.3390/cancers15082195.

Authors

Javad Alizadeh¹, Mahboubeh Kavoosi¹, Navjit Singh¹, Shahrokh Lorzadeh¹, Amir Ravandi², Biniam Kidane^{3

4}, Naseer Ahmed^{4

5}, Fatima Mraiche^{6

7}, Michael R Mowat^{4

8}, Saeid Ghavami^{1

9

10

11}

Affiliations

¹ Department of Human Anatomy and Cell Science, College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada.
² Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Institute of Cardiovascular Sciences, Albrechtsen Research Centre, St. Boniface Hospital, Winnipeg, MB R2H 2A6, Canada.
³ Section of Thoracic Surgery, Department of Surgery, Health Sciences Centre, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3T 6C5, Canada.
⁴ CancerCare Manitoba Research Institute, Winnipeg, MB R3E 0V9, Canada.
⁵ Department of Radiology, Section of Radiation Oncology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
⁶ College of Pharmacy, QU Health, Qatar University, Doha 2713, Qatar.
⁷ Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.
⁸ Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
⁹ Research Institute of Oncology and Hematology, Winnipeg, MB R3E 0V9, Canada.
¹⁰ Faculty of Medicine in Zabrze, Academia of Silesia, 41-800 Zabrze, Poland.
¹¹ Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB R3E 3P5, Canada.

Abstract

Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells that digests damaged organelles and misfolded proteins via lysosomal degradation, is closely associated with metabolism in mammalian cells, acting as a meter of cellular ATP levels. In this review, we discuss the changes in glycolytic and lipid biosynthetic pathways in mammalian cells and their impact on carcinogenesis via the autophagy pathway. In addition, we discuss the impact of these metabolic pathways on autophagy in lung cancer.

Keywords: Bcl2 family protein; Warburg effect; ceramide metabolism; glycolysis; mitophagy; non-small cell lung carcinoma.

Publication types

Review

Grants and funding

S.G., B.K., N.A. and M.M. are supported by the CancerCare Manitoba Operating grant (763117252) funded by CancerCare Manitoba Foundation. J.A. is supported by a Vanier CIHR Ph.D. studentship. Navjit Singh was supported by the Max Rady College of Medicine’s BSc (Med) program.