Assessing within-subject rates of change of placental MRI diffusion metrics in normal pregnancy

Abstract

Purpose: Studying placental development informs when development is abnormal. Most placental MRI studies are cross-sectional and do not study the extent of individual variability throughout pregnancy. We aimed to explore how diffusion MRI measures of placental function and microstructure vary in individual healthy pregnancies throughout gestation.

Methods: Seventy-nine pregnant, low-risk participants (17 scanned twice and 62 scanned once) were included. T₂ -weighted anatomical imaging and a combined multi-echo spin-echo diffusion-weighted sequence were acquired at 3 T. Combined diffusion-relaxometry models were performed using both a $T_2^{*}$ -ADC and a bicompartmental $T_2^{*}$ -intravoxel-incoherent-motion ( $T_2^{*}\text{IVIM}$ ) model fit.

Results: There was a significant decline in placental $T_2^{*}$ and ADC (both P < 0.01) over gestation. These declines are consistent in individuals for $T_2^{*}$ (covariance = -0.47), but not ADC (covariance = -1.04). The $T_2^{*}\text{IVIM}$ model identified a consistent decline in individuals over gestation in $T_2^{*}$ from both the perfusing and diffusing placental compartments, but not in ADC values from either. The placental perfusing compartment fraction increased over gestation (P = 0.0017), but this increase was not consistent in individuals (covariance = 2.57).

Conclusion: Whole placental $T_2^{*}$ and ADC values decrease over gestation, although only $T_2^{*}$ values showed consistent trends within subjects. There was minimal individual variation in rates of change of $T_2^{*}$ values from perfusing and diffusing placental compartments, whereas trends in ADC values from these compartments were less consistent. These findings probably relate to the increased complexity of the bicompartmental $T_2^{*}\text{IVIM}$ model, and differences in how different placental regions evolve at a microstructural level. These placental MRI metrics from low-risk pregnancies provide a useful benchmark for clinical cohorts.

Keywords: T 2 * $$ {\mathrm{T}}_2^{\ast } $$ relaxometry; diffusion imaging; longitudinal imaging; placental MRI.