Intraoperative Radiation Therapy for Gastrointestinal Malignancies

Abstract

Despite improvements in definitive therapy, many patients with gastrointestinal malignancies experience local recurrences or have unresectable disease making subsequent management often challenging and morbid. Although higher doses of radiation may offer improved local control, the ability for dose escalation of external beam radiation therapy is often limited by adjacent radiosensitive structures. Intraoperative radiation therapy allows for additional radiotherapy to be delivered directly to the tumor or areas at highest risk for local recurrence while minimizing toxicity to adjacent structures, offering potentially improved outcomes for patients with unresectable disease or those with a high risk of local recurrence.

Keywords: Gastrointestinal malignancies; Intraoperative radiation therapy; Local control; Pancreatic cancer; Rectal cancer; Recurrence; Unresectable.