Immunogenic sonodynamic therapy for inducing immunogenic cell death and activating antitumor immunity

Ting Wang; Wangrui Peng; Meng Du; Zhiyi Chen

doi:10.3389/fonc.2023.1167105

Immunogenic sonodynamic therapy for inducing immunogenic cell death and activating antitumor immunity

Front Oncol. 2023 Apr 24:13:1167105. doi: 10.3389/fonc.2023.1167105. eCollection 2023.

Authors

Ting Wang^{1

2}, Wangrui Peng^{2

3}, Meng Du^{1

2}, Zhiyi Chen^{1

2

3}

Affiliations

¹ The First Affiliated Hospital, Medical Imaging Centre, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
² Institute of Medical Imaging, Hengyang Medical School, University of South China, Hengyang, China.
³ The Seventh Affiliated Hospital, Hunan Veterans Administration Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

Abstract

Immunotherapy is widely regarded as a promising treatment for cancer. However, the immune effector phase suppression of tumor microenvironment (TME) and the generation of immune-related adverse events limit its application. Research indicates that sonodynamic therapy (SDT) can effectively activate antitumor immunity while killing tumor cells. SDT produces cytotoxic substances of tumors, and then cell apoptosis and immunogenic death occur by selectively activating the sonosensitizer under ultrasound. In recent years, various SDT alone as well as SDT in combination with other therapies have been developed to induce immunogenic cell death (ICD) and enhance immunotherapy. This paper overviews the research progress of SDT and nanotechnology in recent years, including the strategies involving SDT alone, SDT-based synergistic induction of antitumor immunity, and immunotherapy based on SDT for multimodal immunotherapy. Finally, the prospects and challenges of these SDT-based therapies in cancer immunotherapy are discussed.

Keywords: cancer immunotherapy; immunogenic cell death; nanoplatforms; sonodynamic therapy (SDT); tumor therapy.

Publication types

Review

Grants and funding

This work was supported by National Key R&D Program of China (2019YFE0110400), National Natural Science Foundation of China (82272028, 81971621, 82102087), Key R&D Program of Hunan Province (2021SK2035), Natural Science Foundation of Hunan Province (2022JJ30039, 2022JJ40392), Natural Science Foundation of Guangdong Province (2021A1515011177, 2020A1515110628).