Developmental exposure to polycyclic aromatic hydrocarbons (PAHs): Focus on benzo[a]pyrene neurotoxicity

Abstract

Polycyclic Aromatic Hydrocarbons (PAHs) are a class of ubiquitous organic compounds produced during the incomplete combustion or pyrolysis of organic material. Dietary source is the main route for PAH human exposure by environmental contamination, food industrial processing or domestic cooking methods. The most studied PAH is benzo[a]pyrene (B[a]P), due to its harmful and multiple effects on human health: in addition to its well-known carcinogenic effects, emerging evidence indicates that B[a]P also induces neurotoxicity earlier and at lower doses than B[a]P-induced carcinogenicity making B[a]P neurotoxicity relevant to human health risk assessment. Developmental neurotoxicity of B[a]P has indeed received increasing attention: both human and experimental studies provide evidence of detrimental effects of prenatal or early postnatal B[a]P exposure, even at low doses. Indeed, in some of the multi-dose animal studies, maximal adverse effects were observed at lower B[a]P doses, according to a non-monotonic dose-response curve typical of endocrine-disrupting compounds. In substantial agreement with epidemiological studies, both rodents and zebrafish developmentally exposed to B[a]P exhibit long-term changes in multiple behavioural domains, in the absence of overt toxicological effects at birth (e.g. body weight and morphologic abnormalities). Notably, most targeted behavioural responses converge on locomotor activity and emotional profile, often, but not always, leading to a disinhibitory/hyperactive profile.

Keywords: Behaviour; Benzo[a]pyrene; Developmental exposure; Neurotoxicity; Polycyclic aromatic hydrocarbons; Rodents; Zebrafish.