Neuroimmune regulation in Hirschsprung's disease associated enterocolitis

Front Immunol. 2023 Apr 17:14:1127375. doi: 10.3389/fimmu.2023.1127375. eCollection 2023.

Abstract

Neuroimmune pathways are important part of the regulation of inflammatory response. Nerve cells regulate the functions of various immune cells through neurotransmitters, and then participate in the inflammatory immune response. Hirschsprung's disease (HD) is a congenital abnormal development of intestinal neurons, and Hirschsprung-associated enterocolitis (HAEC) is a common complication, which seriously affects the quality of life and even endangers the lives of children. Neuroimmune regulation mediates the occurrence and development of enteritis, which is an important mechanism. However, there is a lack of review on the role of Neuroimmune regulation in enterocolitis associated with Hirschsprung's disease. Therefore, this paper summarizes the characteristics of the interaction between intestinal nerve cells and immune cells, reviews the neuroimmune regulation mechanism of Hirschsprung's disease associated enterocolitis (HAEC), and looks forward to the potential clinical application value.

Keywords: Hirschsprung’s disease enterocolitis; gastroenterology; immunity; neonatology; neuron.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Enterocolitis* / etiology
  • Hirschsprung Disease* / complications
  • Humans
  • Intestines
  • Neuroimmunomodulation
  • Quality of Life

Grants and funding

This work was supported by the National Natural Science Foundation of China 82171699 (JT), 81901989 (DL); Natural Science Foundation of Zhejiang Province LY21H150005 (DL), LY22H040006 (JT); Foundation for The Top-Notch Youth Talent Cultivation Project of Independent Design Project of National Clinical Research Center for Child Health Q21B0007 (DL); Special Fund for the Incubation of Young Clinical Scientist, The Children’s Hospital of Zhejiang University School of Medicine CHZJU2022YS002 (DL).