Sleep and Inflammation: Bidirectional Relationship

Haviva Veler

doi:10.1016/j.jsmc.2023.02.003

Sleep and Inflammation: Bidirectional Relationship

Sleep Med Clin. 2023 Jun;18(2):213-218. doi: 10.1016/j.jsmc.2023.02.003. Epub 2023 Mar 28.

Author

Haviva Veler¹

Affiliation

¹ Pediatric Pulmonology and Sleep Medicine, University of Connecticut School of Medicine, Connecticut Children Medical Center, 85 Seymour Street, Suite 500, Hartford, CT 06106, USA. Electronic address: hveler@connecticutchildren.org.

PMID: 37120163
DOI: 10.1016/j.jsmc.2023.02.003

Abstract

Sleep and inflammatory cytokines have a bidirectional relationship where circadian rhythms influence increase in levels of certain cytokines, and in return, some cytokines induce sleep, as we frequently experience during illnesses. The most commonly studied cytokines, in the context of inflammation and sleep, are interleukin 6 (IL-6), tumor necrosis factor (TNF), and (IL-1). In this article, the author follows the effect of circadian rhythms on blood levels of these cytokines and explores the changes in their levels in conditions that affect sleep, such as obstructive sleep apnea and insomnia.

Keywords: C-reactive protein; Inflammation; Interleukin-6; Sleep; Tumor necrosis factor.

Publication types

Review

MeSH terms

Cytokines*
Humans
Inflammation
Interleukin-6
Sleep*
Tumor Necrosis Factor-alpha

Substances

Cytokines
Interleukin-6
Tumor Necrosis Factor-alpha