Reduced duration mismatch negativity elicited by the multi-feature 'optimal' paradigm in early-phase psychosis

Hayley Riel; Erica D Rudolph; Catrina MacPhee; Philip G Tibbo; Derek J Fisher

doi:10.1016/j.biopsycho.2023.108570

Reduced duration mismatch negativity elicited by the multi-feature 'optimal' paradigm in early-phase psychosis

Biol Psychol. 2023 May:180:108570. doi: 10.1016/j.biopsycho.2023.108570. Epub 2023 Apr 26.

Authors

Hayley Riel¹, Erica D Rudolph², Catrina MacPhee¹, Philip G Tibbo¹, Derek J Fisher³

Affiliations

¹ Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
² Department of Psychology, Saint Mary's University, Halifax, NS, Canada.
³ Department of Psychiatry, Dalhousie University, Halifax, NS, Canada; Department of Psychology, Saint Mary's University, Halifax, NS, Canada; Department of Psychology, Mount Saint Vincent University, Halifax, NS, Canada. Electronic address: derek.fisher@msvu.ca.

PMID: 37116608
DOI: 10.1016/j.biopsycho.2023.108570

Abstract

Background: MMN and P3a are EEG-derived event related potentials that are thought to be prospective biomarkers for schizophrenia and, potentially, early-phase psychosis (EPP).

Methods: EPP (n = 12) and healthy control (HC; n = 35) participants listened to a multi-feature optimal paradigm with five deviant types (gap, duration, location, intensity, and frequency).

Results: There was a significant amplitude difference between the EPP and HC group with duration MMN (p = .02). No significant amplitude differences between groups were found for the P3a waveform. There were several correlations for the EPP group with the BNSS, SOFAS, and PANSS-general questionnaires. Length of illness was not associated with MMN or P3a.

Conclusions: The optimal paradigm is suitable for eliciting multiple deviant types within a short amount of time in both clinical and healthy populations. This study confirms duration MMN deficits within an EPP group and that MMN is related to functional outcomes and positive and negative symptomology.

Keywords: Duration deviant; EEG; ERP; Mismatch negativity; Optimal; P3a; Psychosis; Schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acoustic Stimulation
Electroencephalography
Evoked Potentials
Evoked Potentials, Auditory
Humans
Psychotic Disorders*
Schizophrenia*