Eye of the Tiger: Looking Beyond Neurodegeneration with Brain Iron Accumulation Disorders

J Pediatr Genet. 2021 Feb 17;12(2):163-166. doi: 10.1055/s-0041-1723959. eCollection 2023 Jun.

Abstract

The "eye-of-the-tiger" sign in brain magnetic resonance imaging (MRI) is typically associated with neurodegeneration with brain iron accumulation disorders, especially pantothenate kinase-associated neurodegeneration. However, very similar neuroimaging findings may be seen in other neurodegenerative disorders involving the basal ganglia. We report here a patient with fucosidosis who had MRI brain findings closely resembling the "eye-of-the-tiger" sign.

Keywords: eye-of-the-tiger sign; fucosidosis; neurodegeneration with brain iron accumulation.

Publication types

  • Case Reports