Influence of Timing of Maternal Pertussis Immunization on the Avidity of Transferred Antibodies in Term and Preterm Neonates

Julie Sartoretti; Paola Fontannaz; Begoña Martinez de Tejada; Véronique Othenin-Girard; Antonina Chilin; Barbara Lemaître; Géraldine Blanchard-Rohner; Claire-Anne Siegrist; Christiane Sigrid Eberhardt

doi:10.1093/cid/ciad227

Influence of Timing of Maternal Pertussis Immunization on the Avidity of Transferred Antibodies in Term and Preterm Neonates

Clin Infect Dis. 2023 Aug 22;77(4):645-648. doi: 10.1093/cid/ciad227.

Authors

Julie Sartoretti^{1

2

3}, Paola Fontannaz¹, Begoña Martinez de Tejada^{3

4}, Véronique Othenin-Girard³, Antonina Chilin⁴, Barbara Lemaître⁵, Géraldine Blanchard-Rohner^{1

2

3}, Claire-Anne Siegrist^{1

2

3

6}, Christiane Sigrid Eberhardt^{1

3

6}

Affiliations

¹ Center for Vaccinology and Neonatal Immunology, Department of Pathology-Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
² Division of General Pediatrics, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland.
³ Department for Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
⁴ Division of Obstetrics, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
⁵ Division of Laboratory Medicine, Department of Diagnostics and of Medical Specialties, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
⁶ Center for Vaccinology, University Hospitals of Geneva, Geneva, Switzerland.

Abstract

The timing of maternal pertussis vaccination influences the titers of cord-blood anti-pertussis antibodies. Whether it affects their avidity is unknown. We demonstrate in 298 term and 72 preterm neonates that antibody avidity is independent of the timing of maternal vaccination, whether comparing second with third trimester or intervals before birth.

Keywords: antibody transfer; avidity; maternal pertussis vaccination; preterm neonates; term neonates.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Bacterial*
Female
Humans
Immunity, Maternally-Acquired
Infant, Newborn
Pregnancy
Pregnancy Trimester, Third
Vaccination
Whooping Cough* / prevention & control

Substances

Antibodies, Bacterial