Exosome and virus infection

Yiqiu Peng; Yuxi Yang; Yingying Li; Tingjuan Shi; Yingyi Luan; Chenghong Yin

doi:10.3389/fimmu.2023.1154217

Exosome and virus infection

Front Immunol. 2023 Mar 30:14:1154217. doi: 10.3389/fimmu.2023.1154217. eCollection 2023.

Authors

Yiqiu Peng¹, Yuxi Yang¹, Yingying Li¹, Tingjuan Shi¹, Yingyi Luan¹, Chenghong Yin¹

Affiliation

¹ Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, China.

Abstract

Exosomes are messengers of intercellular communication in monolayer vesicles derived from cells. It affects the pathophysiological process of the body in various diseases, such as tumors, inflammation, and infection. It has been confirmed that exosomes are similar to viruses in biogenesis, and exosome cargo is widely involved in many viruses' replication, transmission, and infection. Simultaneously, virus-associated exosomes can promote immune escape and activate the antiviral immune response of the body, which bidirectionally modulates the immune response. This review focuses on the role of exosomes in HIV, HBV, HCV, and SARS-CoV-2 infection and explores the prospects of exosome development. These insights may be translated into therapeutic measures for viral infections and reduce the disease burden.

Keywords: HBV; HCV; HIV; SARS-CoV-2; exosome; virus infection.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents
COVID-19*
Exosomes*
Humans
SARS-CoV-2
Virus Diseases*

Substances

Antiviral Agents

Grants and funding

This study was supported, in part, by grants from the National Natural Science Foundation of China (Nos. 81873943), and the National Key Research and Development Program of China (Nos. 2016YFC1000100).