Potential pitfalls in the use of real-world data for studying long COVID
Nat Med
.
2023 May;29(5):1040-1043.
doi: 10.1038/s41591-023-02274-y.
Authors
Harrison G Zhang
1
2
3
,
Jacqueline P Honerlaw
2
,
Monika Maripuri
2
,
Malarkodi Jebathilagam Samayamuthu
4
,
Brendin R Beaulieu-Jones
1
,
Huma S Baig
5
,
Sehi L'Yi
1
,
Yuk-Lam Ho
2
,
Michele Morris
4
,
Vidul Ayakulangara Panickan
1
,
Xuan Wang
1
,
Griffin M Weber
1
,
Katherine P Liao
2
3
,
Shyam Visweswaran
4
,
Bryce W Q Tan
6
,
William Yuan
1
,
Nils Gehlenborg
1
,
Sumitra Muralidhar
7
,
Rachel B Ramoni
7
;
Consortium for Clinical Characterization of COVID-19 by EHR (4CE)
;
Isaac S Kohane
#
1
,
Zongqi Xia
#
8
,
Kelly Cho
#
2
,
Tianxi Cai
#
1
2
,
Gabriel A Brat
#
9
Collaborators
Consortium for Clinical Characterization of COVID-19 by EHR (4CE)
:
James R Aaron
,
Giuseppe Agapito
,
Adem Albayrak
,
Giuseppe Albi
,
Mario Alessiani
,
Anna Alloni
,
Danilo F Amendola
,
François Angoulvant
,
Li L L J Anthony
,
Bruce J Aronow
,
Fatima Ashraf
,
Andrew Atz
,
Paul Avillach
,
Paula S Azevedo
,
James Balshi
,
Brett K Beaulieu-Jones
,
Douglas S Bell
,
Antonio Bellasi
,
Riccardo Bellazzi
,
Vincent Benoit
,
Michele Beraghi
,
José Luis Bernal-Sobrino
,
Mélodie Bernaux
,
Romain Bey
,
Surbhi Bhatnagar
,
Alvar Blanco-Martínez
,
Clara-Lea Bonzel
,
John Booth
,
Silvano Bosari
,
Florence T Bourgeois
,
Robert L Bradford
,
Stéphane Bréant
,
Nicholas W Brown
,
Raffaele Bruno
,
William A Bryant
,
Mauro Bucalo
,
Emily Bucholz
,
Anita Burgun
,
Tianxi Cai
,
Mario Cannataro
,
Aldo Carmona
,
Charlotte Caucheteux
,
Julien Champ
,
Jin Chen
,
Krista Y Chen
,
Luca Chiovato
,
Lorenzo Chiudinelli
,
Kelly Cho
,
James J Cimino
,
Tiago K Colicchio
,
Sylvie Cormont
,
Sébastien Cossin
,
Jean B Craig
,
Juan Luis Cruz-Bermúdez
,
Jaime Cruz-Rojo
,
Arianna Dagliati
,
Mohamad Daniar
,
Christel Daniel
,
Priyam Das
,
Batsal Devkota
,
Audrey Dionne
,
Rui Duan
,
Julien Dubiel
,
Scott L DuVall
,
Loic Esteve
,
Hossein Estiri
,
Shirley Fan
,
Robert W Follett
,
Thomas Ganslandt
,
Noelia García-Barrio
,
Lana X Garmire
,
Emily J Getzen
,
Alon Geva
,
Tobias Gradinger
,
Alexandre Gramfort
,
Romain Griffier
,
Nicolas Griffon
,
Olivier Grisel
,
Alba Gutiérrez-Sacristán
,
Larry Han
,
David A Hanauer
,
Christian Haverkamp
,
Derek Y Hazard
,
Bing He
,
Darren W Henderson
,
Martin Hilka
,
John H Holmes
,
Chuan Hong
,
Kenneth M Huling
,
Meghan R Hutch
,
Richard W Issitt
,
Anne Sophie Jannot
,
Vianney Jouhet
,
Ramakanth Kavuluru
,
Mark S Keller
,
Chris J Kennedy
,
Daniel A Key
,
Katie Kirchoff
,
Jeffrey G Klann
,
Ian D Krantz
,
Detlef Kraska
,
Ashok K Krishnamurthy
,
Trang T Le
,
Judith Leblanc
,
Guillaume Lemaitre
,
Leslie Lenert
,
Damien Leprovost
,
Molei Liu
,
Ne Hooi Will Loh
,
Qi Long
,
Sara Lozano-Zahonero
,
Yuan Luo
,
Kristine E Lynch
,
Sadiqa Mahmood
,
Sarah E Maidlow
,
Adeline Makoudjou
,
Alberto Malovini
,
Kenneth D Mandl
,
Chengsheng Mao
,
Anupama Maram
,
Patricia Martel
,
Marcelo R Martins
,
Jayson S Marwaha
,
Aaron J Masino
,
Maria Mazzitelli
,
Arthur Mensch
,
Marianna Milano
,
Marcos F Minicucci
,
Bertrand Moal
,
Taha Mohseni Ahooyi
,
Jason H Moore
,
Cinta Moraleda
,
Jeffrey S Morris
,
Karyn L Moshal
,
Sajad Mousavi
,
Danielle L Mowery
,
Douglas A Murad
,
Shawn N Murphy
,
Thomas P Naughton
,
Carlos Tadeu Breda Neto
,
Antoine Neuraz
,
Jane Newburger
,
Kee Yuan Ngiam
,
Wanjiku F M Njoroge
,
James B Norman
,
Jihad Obeid
,
Marina P Okoshi
,
Karen L Olson
,
Gilbert S Omenn
,
Nina Orlova
,
Brian D Ostasiewski
,
Nathan P Palmer
,
Nicolas Paris
,
Lav P Patel
,
Miguel Pedrera-Jiménez
,
Emily R Pfaff
,
Ashley C Pfaff
,
Danielle Pillion
,
Sara Pizzimenti
,
Hans U Prokosch
,
Robson A Prudente
,
Andrea Prunotto
,
Víctor Quirós-González
,
Rachel B Ramoni
,
Maryna Raskin
,
Siegbert Rieg
,
Gustavo Roig-Domínguez
,
Pablo Rojo
,
Paula Rubio-Mayo
,
Paolo Sacchi
,
Carlos Sáez
,
Elisa Salamanca
,
Malarkodi Jebathilagam Samayamuthu
,
L Nelson Sanchez-Pinto
,
Arnaud Sandrin
,
Nandhini Santhanam
,
Janaina C C Santos
,
Fernando J Sanz Vidorreta
,
Maria Savino
,
Emily R Schriver
,
Petra Schubert
,
Juergen Schuettler
,
Luigia Scudeller
,
Neil J Sebire
,
Pablo Serrano-Balazote
,
Patricia Serre
,
Arnaud Serret-Larmande
,
Mohsin Shah
,
Zahra Shakeri Hossein Abad
,
Domenick Silvio
,
Piotr Sliz
,
Jiyeon Son
,
Charles Sonday
,
Andrew M South
,
Anastasia Spiridou
,
Zachary H Strasser
,
Amelia L M Tan
,
Byorn W L Tan
,
Suzana E Tanni
,
Deanne M Taylor
,
Ana I Terriza-Torres
,
Valentina Tibollo
,
Patric Tippmann
,
Emma M S Toh
,
Carlo Torti
,
Enrico M Trecarichi
,
Yi-Ju Tseng
,
Andrew K Vallejos
,
Gael Varoquaux
,
Margaret E Vella
,
Guillaume Verdy
,
Jill-Jênn Vie
,
Michele Vitacca
,
Kavishwar B Wagholikar
,
Lemuel R Waitman
,
Demian Wassermann
,
Martin Wolkewitz
,
Scott Wong
,
Xin Xiong
,
Ye Ye
,
Nadir Yehya
,
Alberto Zambelli
,
Harrison G Zhang
,
Daniela Zöller
,
Valentina Zuccaro
,
Chiara Zucco
Affiliations
1
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
2
Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
3
Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA, USA.
4
Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
5
Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.
6
Department of Medicine, National University Hospital, Singapore, Singapore, Singapore.
7
Office of Research and Development, US Department of Veterans Affairs, Washington DC, USA.
8
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
9
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. gbrat@bidmc.harvard.edu.
#
Contributed equally.
PMID:
37055567
PMCID:
PMC10205658
DOI:
10.1038/s41591-023-02274-y
No abstract available
Publication types
Letter
Research Support, N.I.H., Extramural
MeSH terms
COVID-19*
Humans
Post-Acute COVID-19 Syndrome
Research
Grants and funding
T15 LM007092/LM/NLM NIH HHS/United States
FS/19/52/34563/BHF_/British Heart Foundation/United Kingdom
R01 LM013345/LM/NLM NIH HHS/United States
R01 NS098023/NS/NINDS NIH HHS/United States
R01 NS124882/NS/NINDS NIH HHS/United States