Advances and potential of omics studies for understanding the development of food allergy

Sayantani B Sindher; Andrew R Chin; Nima Aghaeepour; Lawrence Prince; Holden Maecker; Gary M Shaw; David K Stevenson; Kari C Nadeau; Michael Snyder; Purvesh Khatri; Scott D Boyd; Virginia D Winn; Martin S Angst; R Sharon Chinthrajah

doi:10.3389/falgy.2023.1149008

Advances and potential of omics studies for understanding the development of food allergy

Front Allergy. 2023 Mar 24:4:1149008. doi: 10.3389/falgy.2023.1149008. eCollection 2023.

Authors

Sayantani B Sindher¹, Andrew R Chin¹, Nima Aghaeepour^{2

3

4}, Lawrence Prince³, Holden Maecker⁵, Gary M Shaw³, David K Stevenson³, Kari C Nadeau¹, Michael Snyder⁶, Purvesh Khatri⁵, Scott D Boyd^{1

7}, Virginia D Winn⁸, Martin S Angst², R Sharon Chinthrajah¹

Affiliations

¹ Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Palo Alto, CA, United States.
² Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, United States.
³ Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, United States.
⁴ Department of Biomedical Data Science, Stanford University School of Medicine, Palo Alto, CA, United States.
⁵ Department of Medicine, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Palo Alto, CA, United States.
⁶ Department of Genetics, Stanford University, Palo Alto, CA, United States.
⁷ Department of Pathology, Stanford University, Palo Alto, CA, United States.
⁸ Department of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, CA, United States.

Abstract

The prevalence of food allergy continues to rise globally, carrying with it substantial safety, economic, and emotional burdens. Although preventative strategies do exist, the heterogeneity of allergy trajectories and clinical phenotypes has made it difficult to identify patients who would benefit from these strategies. Therefore, further studies investigating the molecular mechanisms that differentiate these trajectories are needed. Large-scale omics studies have identified key insights into the molecular mechanisms for many different diseases, however the application of these technologies to uncover the drivers of food allergy development is in its infancy. Here we review the use of omics approaches in food allergy and highlight key gaps in knowledge for applying these technologies for the characterization of food allergy development.

Keywords: disease development; food allergy (FA); genomics; metabolomics; proteomics; transcriptomics.

Publication types

Review

Abstract

Publication types

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