Histone chaperones: A multinodal highway network inside the cell

Zhiming Li; Zhiguo Zhang

doi:10.1016/j.molcel.2023.03.004

Histone chaperones: A multinodal highway network inside the cell

Mol Cell. 2023 Apr 6;83(7):1024-1026. doi: 10.1016/j.molcel.2023.03.004.

Authors

Zhiming Li¹, Zhiguo Zhang²

Affiliations

¹ Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.
² Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: zz2401@cumc.columbia.edu.

Abstract

Histone chaperones participate in the biogenesis, transportation, and deposition of histones. They contribute to processes impacted by nucleosomes including DNA replication, transcription, and epigenetic inheritance. In this issue, Carraro et al.¹ reveal an interconnected chaperone network and a surprising function of histone chaperone DAXX in de novo deposition of H3.3K9me3.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

DNA Replication
Histone Chaperones* / genetics
Histone Chaperones* / metabolism
Histones* / genetics
Histones* / metabolism
Molecular Chaperones / genetics
Nucleosomes / genetics

Substances

Histone Chaperones
Histones
Nucleosomes
Molecular Chaperones

Grants and funding

R35 GM118015/GM/NIGMS NIH HHS/United States