Human hematopoietic stem cells expand beyond cytokines

Alanna Van Huizen; Shannon McKinney-Freeman

doi:10.1016/j.stem.2023.03.011

Human hematopoietic stem cells expand beyond cytokines

Cell Stem Cell. 2023 Apr 6;30(4):343-344. doi: 10.1016/j.stem.2023.03.011.

Authors

Alanna Van Huizen¹, Shannon McKinney-Freeman²

Affiliations

¹ Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
² Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: shannon.mckinney-freeman@stjude.org.

PMID: 37028400
DOI: 10.1016/j.stem.2023.03.011

Abstract

The paucity of hematopoietic stem cells (HSCs) presents a challenge for both transplantation and the study of HSCs.¹ Sakurai et al.² now present a cytokine-free culture system for robust ex vivo expansion of functional human HSCs that may lead to exciting clinical outcomes.

Publication types

Comment

MeSH terms

Cells, Cultured
Cytokines*
Fetal Blood
Hematopoietic Stem Cell Transplantation*
Hematopoietic Stem Cells
Humans

Substances

Cytokines