Beta-blockade improves right ventricular diastolic function in exercising pulmonary arterial hypertension

Chinthaka B Samaranayake; Aleksander Kempny; Robert Naeije; Michael Gatzoulis; Laura C Price; Konstantinos Dimopoulos; Lan Zhao; Stephen J Wort; Colm McCabe

doi:10.1183/13993003.00144-2023

Beta-blockade improves right ventricular diastolic function in exercising pulmonary arterial hypertension

Eur Respir J. 2023 May 18;61(5):2300144. doi: 10.1183/13993003.00144-2023. Print 2023 May.

Authors

Chinthaka B Samaranayake¹, Aleksander Kempny^{1

2}, Robert Naeije³, Michael Gatzoulis^{1

2}, Laura C Price^{1

2}, Konstantinos Dimopoulos^{1

2}, Lan Zhao², Stephen J Wort^{1

2}, Colm McCabe^{4

2}

Affiliations

¹ National Pulmonary Hypertension Service, Royal Brompton Hospital, London, UK.
² National Heart and Lung Institute, Imperial College, London, UK.
³ Free University of Brussels, Brussels, Belgium.
⁴ National Pulmonary Hypertension Service, Royal Brompton Hospital, London, UK c.mccabe2@rbht.nhs.uk.

Abstract

Beta-blockade improves right ventricular exercise diastolic function in pulmonary arterial hypertension via improved heterometric adaptation to the increase in venous return. Further studies are required to determine mechanisms underlying this change. https://bit.ly/3ZMT8bu

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Familial Primary Pulmonary Hypertension
Humans
Hypertension, Pulmonary* / drug therapy
Pulmonary Arterial Hypertension* / drug therapy
Ventricular Dysfunction, Right* / drug therapy
Ventricular Function, Left
Ventricular Function, Right