Abstract
A direct comparative study of the distribution of intact and Fab2(1) fragments of mouse monoclonal anti-human chorionic gonadotrophin antibody, W14A, in nude mice bearing a human choriocarcinoma xenograft, indicates that the tumour:blood ratio is generally improved with fragments. Some parameters which may determine the distribution are outlined.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Monoclonal / analysis*
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Choriocarcinoma / immunology*
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Chorionic Gonadotropin / immunology*
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Electrophoresis, Polyacrylamide Gel
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Female
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Humans
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Immune Sera / immunology
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Immunoglobulin Fab Fragments / analysis*
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Iodine Radioisotopes
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Mice
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Mice, Nude
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Neoplasm Transplantation
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Pregnancy
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Transplantation, Heterologous
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Uterine Neoplasms / immunology*
Substances
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Antibodies, Monoclonal
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Chorionic Gonadotropin
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Immune Sera
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Immunoglobulin Fab Fragments
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Iodine Radioisotopes