Novel activity of melatonin. Its chemotactic effect on retinal pigment epithelial cells

Ophthalmic Res. 1987;19(4):226-9. doi: 10.1159/000265498.

Abstract

Melatonin (100 nM-100 microM) showed a chemotactic action on cultured chick retinal pigment epithelial cells. This effect was equivalent to that of N-formyl methionyl-leucyl-phenylalanine. Other methoxyindole derivatives had no or less chemotactic effects than melatonin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Movement / drug effects
  • Chemotactic Factors / pharmacology*
  • Chickens
  • Culture Techniques
  • Dose-Response Relationship, Drug
  • Melatonin / pharmacology*
  • N-Formylmethionine Leucyl-Phenylalanine / pharmacology
  • Osmolar Concentration
  • Pigment Epithelium of Eye / cytology
  • Pigment Epithelium of Eye / drug effects*

Substances

  • Chemotactic Factors
  • N-Formylmethionine Leucyl-Phenylalanine
  • Melatonin