Obesity does not modify the effect of continuous positive airway pressure on insulin resistance in adults with obstructive sleep apnoea

Victoria M Pak; David G Maislin; Brendan T Keenan; Xiaofeng Guo; Ray Townsend; Bryndis Benediktsdottir; Allan I Pack; Thorarinn Gislason; Samuel T Kuna

doi:10.1183/23120541.00443-2022

Obesity does not modify the effect of continuous positive airway pressure on insulin resistance in adults with obstructive sleep apnoea

ERJ Open Res. 2023 Mar 13;9(2):00443-2022. doi: 10.1183/23120541.00443-2022. eCollection 2023 Mar.

Authors

Victoria M Pak^{1

2}, David G Maislin³, Brendan T Keenan³, Xiaofeng Guo³, Ray Townsend⁴, Bryndis Benediktsdottir^{5

6}, Allan I Pack³, Thorarinn Gislason^{5

6}, Samuel T Kuna^{3

7}

Affiliations

¹ Emory University, School of Nursing, Atlanta, GA, USA.
² Emory University, Rollins School of Public Health, Department of Epidemiology, Atlanta, GA, USA.
³ Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
⁴ Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
⁵ Department of Sleep Medicine, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.
⁶ Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
⁷ Sleep Medicine Section, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.

Abstract

This study found no evidence that obesity significantly modifies the effect of 4 months of CPAP treatment on HOMA-IR. Longer duration of CPAP treatment may be needed in order to reduce insulin resistance and determine whether obesity modifies the effect. https://bit.ly/3CtX7jZ.