From Basic Science to Clinical Practice: The Role of Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A)/p90 in Cancer

Beibei Chen; Huihui Hu; Xiaobing Chen

doi:10.3389/fgene.2023.1110656

From Basic Science to Clinical Practice: The Role of Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A)/p90 in Cancer

Front Genet. 2023 Feb 24:14:1110656. doi: 10.3389/fgene.2023.1110656. eCollection 2023.

Authors

Beibei Chen^{1

2}, Huihui Hu^{1

2}, Xiaobing Chen^{1

2}

Affiliations

¹ Department of Medical Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China.
² Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer, Zhengzhou, Henan, China.

Abstract

Cancerous inhibitor of protein phosphatase 2A (CIP2A), initially reported as a tumor-associated antigen (known as p90), is highly expressed in most solid and hematological tumors. The interaction of CIP2A/p90, protein phosphatase 2A (PP2A), and c-Myc can hinder the function of PP2A toward c-Myc S62 induction, thus stabilizing c-Myc protein, which represents a potential role of CIP2A/p90 in tumorigeneses such as cell proliferation, invasion, and migration, as well as cancer drug resistance. The signaling pathways and regulation networks of CIP2A/p90 are complex and not yet fully understood. Many previous studies have also demonstrated that CIP2A/p90 can be used as a potential therapeutic cancer target. In addition, the autoantibody against CIP2A/p90 in sera may be used as a promising biomarker in the diagnosis of certain types of cancer. In this Review, we focus on recent advances relating to CIP2A/p90 and their implications for future research.

Keywords: CIP2A/p90; biomarker; cancer; prognosis; signaling pathways; tumor-associated antigen (TAA).

Publication types

Review

Grants and funding

This work was supported by the Medical Science and Technique Foundation of Henan Province (LHGJ20210172), the Science and Technique Foundation of Henan Province (222102310424), and the Project of international scientific and technological cooperation in Henan Province (182102410023).