Adverse Effects of Sugammadex on the Cardiovascular System

Cureus. 2023 Feb 7;15(2):e34728. doi: 10.7759/cureus.34728. eCollection 2023 Feb.

Abstract

Perioperative anaphylaxis is rare but potentially life-threatening. Although the most common causative agents are muscle relaxants and antibiotics, there have been several case reports of sugammadex-induced anaphylactic reactions. Though most cases of perioperative anaphylaxis present after induction, sugammadex anaphylaxis presents at the end of the case, sometimes in unmonitored situations such as after extubation or during transport to the recovery unit. Here we report a case of suspected sugammadex-induced anaphylaxis that led to cardiac arrest. We emphasize that vigilance is required when a high dose of sugammadex is used for the reversal of neuromuscular blockade.

Keywords: allergic; allergic reaction; allergy and anaphylaxis; cardiac arrest; sugammadex dosing and timing.

Publication types

  • Case Reports