A "Two-in-One Hit" Model of Shortcut Carcinogenesis in MLH1 Lynch Syndrome Carriers

Affiliations

• ¹ Department of Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Centre, Heidelberg, Germany.
• ² Institute of Pathology, Heidelberg University Hospital, German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany.
• ³ Faculty of Medicine and Health Technology, Tampere University, Tays Cancer Center, Tampere University Hospital, Tampere, Finland; Applied Tumor Genomics Research Program, Department of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki, Finland.
• ⁴ National Center for Hereditary Tumor Syndromes, Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
• ⁵ Department of Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Centre (DKFZ), Heidelberg, Germany. Electronic address: matthias.kloor@med.uni-heidelberg.de.
• ⁶ Institute of Pathology, University Hospital Leipzig, Leipzig, Germany.
• ⁷ Department of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
• ⁸ Department of General Pathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
• ⁹ Institute of Pathology, University Hospital Leipzig, Leipzig, Germany; Institute of Pathology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
• ¹⁰ Institute of Pathology, University Hospital Bonn, Bonn, Germany; National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany.
• ¹¹ Engineering Mathematics and Computing Lab, Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany; Data Mining and Uncertainty Quantification (DMQ), Heidelberg Institute for Theoretical Studies, Heidelberg, Germany.
• ¹² Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland; Department of Surgery, Central Finland Hospital Nova, Jyväskylä, Finland.
• ¹³ National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.