Objective: To investigate the efficacy and safety of a new endoscopic anastomosis clip in the treatment of defects after endoscopic full-thickness resection (EFTR). Methods: Retrospective cohort study. Fourteen patients [4 males and 10 females, aged (55.9±8.2) years (45-69 years)] with gastric submucosal tumors underwent EFTR at the First Affiliated Hospital of Soochow University were included from December 2018 to January 2021. Patients were divided into new anastomotic clamp group (n=6) and nylon ring combined with metal clips group (n=8). Preoperative endoscopic ultrasound examinations were required to all patients to evaluate the wound condition. The size of the defect, operation time required for wound closure, success rate of closure, postoperative gastric tube placement time, postoperative hospital stay, incidence of complications, preoperative and postoperative serological indexes were compared between the two groups. All patients were followed up after the operation, among which the general endoscopy was reviewed in the first month after the operation, and the telephone and questionnaire follow-up were used in the second, third, sixth month and one year after the operation to evaluate the therapeutic effect of the new endoscopic anastomosis clip and nylon rope combined with metal clip after the EFTR operation. Results: Both groups successfully completed EFTR and were successfully closed. There was no significant difference between the age, tumor diameter and defect diameter of the two groups (all P>0.05). Compared with the nylon ring combined with metal clip group, the operation time of the new anastomotic clip group was shortened [(5.0±1.8) minutes vs (35.6±10.2) minutes, P<0.001]. The operation time was shortened [(62.2±12.5) minutes vs (92.5±0.2) minutes, P=0.007]. Postoperative fasting time decreased [(2.8±0.8) days vs (4.9±1.1) days, P=0.002]. The hospital stay after operation was also shortened [(5.2±0.8) days vs (6.9±1.5) days, P=0.023]. The total intraoperative bleeding volume decreased [(20.00±5.48) ml vs (35.63±14.75) ml, P=0.031]. The patients in both groups received endoscopic examination 1 month after operation, and there was no delayed perforation and bleeding after operation. There was no obvious symptoms of discomfort. Conclusion: The new anastomotic clamp is suitable for the treatment of full-thickness gastric wall defects after EFTR, and shows advantages of shorter operation, less bleeding, and fewer postoperative complications.
目的： 探讨新型内镜吻合夹对治疗内镜下胃壁全层切除术（EFTR）后缺损的疗效及安全性。 方法： 回顾性队列研究，纳入2018年12月至2021年1月于苏州大学附属第一医院因胃黏膜下肿瘤入院而接受EFTR术的14例患者，男4例，女10例，年龄（55.9±8.2）岁（45~69岁）。其中闭合创面使用新型吻合夹6例（新型吻合夹组），使用尼龙绳联合金属夹8例（尼龙圈联合金属夹组）。所有患者术前均完善超声内镜检查，术后均行普通白光内镜检查以评估创面情况。比较两组患者的创面大小、闭合创面所需的操作时间、闭合成功率、术后胃管放置时间、术后住院时间及并发症的发生情况，术前及术后相关血清学指标等。术后对所有患者进行随访，其中术后第1个月复查普通内镜，术后第2、3、6个月及术后1年采用电话及问卷随访形式，评估新型内镜吻合夹和尼龙绳联合金属夹在EFTR术后的治疗效果。 结果： 两组患者均顺利完成内镜下全层切除术，均成功闭合。两组患者的年龄、肿瘤直径、缺损直径间的差异均无统计学意义（均P>0.05）。和尼龙圈联合金属夹组相比，新型吻合夹组操作时间缩短［（5.0±1.8）min比（35.6±10.2）min，P<0.001］；手术时间缩短［（62.2±12.5）min比（92.5±0.2）min，P=0.007］；术后禁食时间减少［（2.8±0.8）d比（4.9±1.1）d，P=0.002］；术后住院时间也缩短［（5.2±0.8）d比（6.9±1.5）d，P=0.023］；术中总出血量减少［（20.00±5.48）ml比（35.63±14.75）ml，P=0.031］。两组患者均在术后1个月接受内镜检查，均未出现术后迟发穿孔及出血；均无明显不适症状。 结论： 新型内镜吻合夹对于治疗EFTR术后造成的胃壁全层缺损效果良好，具有术中操作快、出血少及术后并发症少等优点。.