Antimalarial activity of a riboflavin analog against Plasmodium vinckei in vivo and Plasmodium falciparum in vitro

Am J Trop Med Hyg. 1987 Nov;37(3):495-500. doi: 10.4269/ajtmh.1987.37.495.

Abstract

The riboflavin analog 10-(4'-chlorophenyl)-3-methylflavin was found to have significant activity against Plasmodium vinckei vinckei when administered orally and parenterally; it was active against P. falciparum in culture. It inhibited mouse erythrocyte glutathione reductase in a dose-dependent manner. When administered orally, 5-deazariboflavin was not active in vivo although it has been shown to have activity against P. falciparum in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Antimalarials / pharmacology
  • Antimalarials / therapeutic use*
  • Drug Evaluation, Preclinical
  • Female
  • Injections, Intraperitoneal
  • Malaria / drug therapy*
  • Mice
  • Mice, Inbred CBA
  • NADH, NADPH Oxidoreductases / antagonists & inhibitors
  • Plasmodium / drug effects*
  • Riboflavin / analogs & derivatives*

Substances

  • Antimalarials
  • NADH, NADPH Oxidoreductases
  • Cystine reductase
  • Riboflavin