Vibrational coupling with O-H stretching increases catalytic efficiency of sucrase in Fabry-Pérot microcavity

Jiaqi Bai; Zixin Wang; Chengjian Zhong; Shaojie Hou; Jiaqi Lian; Qiankang Si; Feng Gao; Feng Zhang

doi:10.1016/j.bbrc.2023.02.025

Vibrational coupling with O-H stretching increases catalytic efficiency of sucrase in Fabry-Pérot microcavity

Biochem Biophys Res Commun. 2023 Apr 16:652:31-34. doi: 10.1016/j.bbrc.2023.02.025. Epub 2023 Feb 12.

Authors

Jiaqi Bai¹, Zixin Wang², Chengjian Zhong¹, Shaojie Hou¹, Jiaqi Lian², Qiankang Si², Feng Gao³, Feng Zhang⁴

Affiliations

¹ The School of Biomedical Engineering, Guangzhou Medical University, Xinzao Town, Panyu District, Guangzhou, 511436, China.
² Key Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, University of Shanghai for Science and Technology, Shanghai, 200093, China.
³ Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, China.
⁴ The School of Biomedical Engineering, Guangzhou Medical University, Xinzao Town, Panyu District, Guangzhou, 511436, China; Key Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, University of Shanghai for Science and Technology, Shanghai, 200093, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, China. Electronic address: fzhang@usst.edu.cn.

PMID: 36809702
DOI: 10.1016/j.bbrc.2023.02.025

Abstract

Vibrational strong coupling (VSC) has been reported as a polariton-based method for modulating the rate of biochemical reactions. Herein, we studied how VSC modulates the sucrose hydrolysis. By monitoring the refractive index-induced shift of Fabry-Pérot microcavity, in which the catalytic efficiency of sucrose hydrolysis can be increased at least two times, as VSC was tuned to resonate with the stretching vibration of O-H bonds. This research provides new evidence for applying VSC in life sciences, which holds great promise to improving enzymatic industries.

Keywords: Catalysis efficiency; Fabry–Pérot microcavity; Hydrolysis reaction; Sucrase; Vibrational strong coupling.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Science Disciplines*
Catalysis
Sucrase*
Sucrose
Vibration

Substances

Sucrase
Sucrose