Loss of Rb1 Associated With the Onset of Acquired Resistance to Trastuzumab Deruxtecan in TP53-/HER2-Mutated Non-Small-Cell Lung Cancer: Case Series

JCO Precis Oncol. 2023 Feb:7:e2200476. doi: 10.1200/PO.22.00476.

Authors

Ashish Gupta¹, Karan Jatwani¹, Kush Gupta², Jingxin Qiu³, Grace K Dy¹

Affiliations

¹ Department of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY.
² Department of Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA.
³ Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY.

PMID: 36809053
DOI: 10.1200/PO.22.00476

No abstract available

MeSH terms

Camptothecin
Carcinoma, Non-Small-Cell Lung*
Humans
Lung Neoplasms*
Retinoblastoma Binding Proteins
Trastuzumab
Tumor Suppressor Protein p53
Ubiquitin-Protein Ligases

Substances

trastuzumab deruxtecan
Trastuzumab
Camptothecin
TP53 protein, human
Tumor Suppressor Protein p53
RB1 protein, human
Ubiquitin-Protein Ligases
Retinoblastoma Binding Proteins