Polygenic risk scores are associated with atrial electrophysiologic substrate abnormalities and outcomes after atrial fibrillation catheter ablation

Heart Rhythm. 2023 Aug;20(8):1188-1194. doi: 10.1016/j.hrthm.2023.02.011. Epub 2023 Feb 16.

¹ Department of Cardiology, Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
² Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.
³ Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia; Heart Centre, The Alfred Hospital, Melbourne, Victoria, Australia.
⁴ Department of Cardiology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
⁵ Kasturba Medical College, Manipal, Karnataka, India.
⁶ Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, New South Wales, Australia.
⁷ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
⁸ Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Kensington, New South Wales, Australia; Cardiology Department, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.
⁹ Department of Cardiology, Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia. Electronic address: jon.kalman@mh.org.au.

Abstract

Keywords: Atrial fibrillation; Catheter ablation; High density mapping; Left atrial substrate; Polygenic risk score.